Closed-loop bioelectronic medicine for diabetes management. Citation: (Gonzalez, 2020)

Research in neuromodulation has led to new therapeutic approaches to advance the field of bioelectronic medicine. Bioelectronic medicine exploits the fact that every organ in our bodies is neurally innervated and thus electrical interfacing with peripheral nerves can be a potential pathway for diagnosing or treating diseases such as diabetes. Aspects of this medicine share similarities to the theoretical concepts of clinical acupuncture, and align with research in neuro-auricular modulation (whether transcutaneous auricular stimulation being researched by neurologists, or the laser-, needle-, and electro-stimulation approaches of Auricular Medicine).

Research into neuromodulation for improving glucose control in people with diabetes, including regulation of gastric emptying, insulin sensitivity, and secretion of pancreatic hormones is leading to the development of surgical implant devices using closed-loop strategies to provide effective, specific and safe interfacing with the nervous system. This article referenced, presents an overview of the state-of-the-art for closed-loop neuromodulation systems in relation to diabetes and a discussion on the future of related opportunities for management of this chronic disease. Read the full paper on PubMed.


CIAM editor’s note: The well-funded research driven by the biomedical device industry, is helping present neurological research in relevant support of the neuro-functional basis of Auricular Medicine.



Güemes Gonzalez A, Etienne-Cummings R, Georgiou P. Closed-loop bioelectronic medicine for diabetes management. Bioelectron Med. 2020 May 15;6:11. doi: 10.1186/s42234-020-00046-4. PMID: 32467827; PMCID: PMC7227365.

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