Chronic inflammation in the etiology of disease across the life span. Citation: (Furman, 2019)

Chronic inflammatory diseases have been recognized as the most significant cause of death in the world today, with more than 50% of all deaths being attributable to inflammation-related diseases such as ischemic heart disease, stroke, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease (NAFLD) and autoimmune and neurodegenerative conditions[2]. Evidence is emerging that the risk of developing chronic inflammation can be traced back to early development, and its effects are now known to persist throughout the life span to affect adulthood health and risk of mortality[3-5].

The Importance of Considering all Contributing Factors

The article on chronic inflammation in the etiology of disease (Furman 2019), describe these effects and out-lines some promising avenues for future research and intervention. The article also offers insight on factors involved in, what is an  enormous complexity of, the inflammatory response.  

Beyond factors including chronic infections, microbiome dysbiosis, physical activity, nutrition, social & lifestyle, environmental toxicants, SCI and disease risk are hypothesized to be perpetuated transgenerationally. So, as Furman et al argue, there is a great need for studies to address the equally complex anti-inflammatory regulatory pathways relevant for influencing inflammation-related disease risk.[1]

An Inflammation Guide for Auricular Testing

The overview of this complexity lends itself to a comprehensive list that can act as a guide for possible testing using Auricular Medicine, for example the testing of...

  • Interferon point and possibly associated functional points, energy points, and medication analogue points, as they relate to inflammatory response (i.e. PGE1, Master Point of Regulation, Cortisone, just to name a few)   
  • Nutrition (vitamins and minerals), especially deficiencies in micronutrients, including zinc[6] and magnesium[7], which are caused by eating processed or refined foods that are low in vitamins and minerals, and having suboptimal omega-3 levels[8], which impacts the resolution phase of inflammation.[see footnote] Don’t forget to possibly consider energy points such as the “Master Point of Regulation” and “Master Point of Qi Flow” according to Bahr, as these influence stimulation of nutrition regulation[9]
  • Miasms (see Q&A with Dr. Frank Bahr, Part 2, in How to Treat PTSD and Trauma of the Soul, and the discussion negative Qi in the Governor Vessel 4-15, along the timeline related to epigenetic inheritance)
  • Constitution (perhaps especially physical and functional weaknesses related to the chronic diseases, i.e. CVD, kidney disease, diabetes, and others, for which inflammation significantly predicts risk).
  • Emotional points as they may relate to lifestyle and psychological factors including stress, sleep, depression, etc.
  • Toxicities as may be related to environmental factors

Editor’s note: A broad overview of approaches to testing, is presented by Dr. Bahr in the course, The Most Important Frequencies in Auricular Medicine (watch on YouTube).

 

Footnote: Longchain omega-3 fatty acids—especially eicosapentaenoic acid and docosahexaenoic acid—modulate the expression of genes involved in metabolism and inflammation[8]. More importantly, they are precursors to molecules such as resolvins, maresins and protectins that are involved in the resolution of inflammation[10-11].

References:

[1] Furman D, Campisi J, Verdin E, et al. Chronic inflammation in the etiology of disease across the life span. Nat Med. 2019;25(12):1822-1832. doi:10.1038/s41591-019-0675-0

[2] GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 392, 1736–1788 (2018). [PMC free article] [PubMed] []

[3] Miller GE, Chen E & Parker KJ Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms. Psychol. Bull 137, 959–997 (2011). [PMC free article][PubMed] []

[4] Fleming TP et al. Origins of lifetime health around the time of conception: causes and consequences. Lancet 391, 1842–1852 (2018). [PMC free article] [PubMed] []

[5] Renz H et al. An exposome perspective: early-life events and immune development in a changing world. J. Allergy Clin. Immunol 140, 24–40 (2017). [PubMed] []

[6] Bonaventura P, Benedetti G, Albarède F & Miossec P Zinc and its role in immunity and inflammation. Autoimm. Rev 14, 277–285 (2015). [PubMed] []

[7] Nielsen FH Effects of magnesium depletion on inflammation in chronic disease. Curr. Opin. Clin. Nutr. Metab. Care 17, 525–530 (2014). [PubMed] []

[8] Calder PC Omega-3 fatty acids and inflammatory processes: from molecules to man. Biochem. Soc. Trans 45, 1105–1115 (2017). [PubMed] []

[9] Strittmatter B. Chapter 6: Ear Acupuncture: A Precise Pocket Atlas Based on the Works of Nogier/Bahr. 2nd ed. Georg Thieme Verlag; 2011:252-255.

[10] Serhan CN Pro-resolving lipid mediators are leads for resolution physiology. Nature 510, 92–101 (2014). [PMC free article] [PubMed] []

[11] Serhan CN & Levy BD Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators. J. Clin. Invest 128, 2657–2669 (2018). [PMC free article] [PubMed] []


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