Vagus Nerve Stimulation for Posttraumatic Stress Disorder in 2021 review by the Psychological Health Center of Excellence of the Department of Defense

The Psychological Health Center of Excellence of the Defense Health Agency in the Department of Defense has released a Psych Health Evidence Brief on the use of vagus nerve stimulation (VNS) for Posttraumatic Stress Disorder (PTSD). Although the 2021 brief falls short of recommending VNS for treatment of PTSD, it shows recognition of a treatment approach that is gaining rapid momentum even just since 2020.[1] In fact, transcutaneous auricular vagus nerve stimulation (taVNS) is treatment ap...


Stress and Tinnitus; Transcutaneous Auricular Vagal Nerve Stimulation Attenuates Tinnitus-Triggered Stress Reaction. Citation: (Ylikoski 2020)

Tinnitus can become a strong stressor for some individuals, and lead to an imbalance of the autonomous nervous system resulting in reduced parasympathetic activity which may manifest as sleep disturbances, anxiety and even depression. Transcutaneous auricular Vagus Nerve Stimulation (taVNS) has been shown to activate the vagal pathways, and a therapeutic alternative in health conditions such as tinnitus-related mental stress (TRMS). In a retrospective study of 171 TRMS patients, suffering fro...


Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression. Citation: (Liu, 2020)

Review article on the potential of transcutaneous auricular vagus nerve stimulation (taVNS) in managing depression — and as it possibly relates to pain and other chronic conditions affected by negative emotional affect and psychological conditions such as depression.   Reference: Liu, CH., Yang, MH., Zhang, GZ. et al. Neural networks and the anti-inflammatory effect of transcutaneous auricular vagus nerve stimulation in depression. J Neuroinflammation 17, 54 (2020). https://doi.org/10.1186/s1...


Current Directions in the Auricular Vagus Nerve Stimulation I – A Physiological Perspective. Citation: (Kaniuses, 2019)

The only place on the body where the vagus nerve (VN) sends its only peripheral branch is on the outer ear. The auricle is where this VN branch surfaces to form a cutaneous receptive field in the pinna of the ear — an area responsive to peripheral nerve stimulation. Thus, the auricle allows for easy access for auricular (and transcutaneous auricular) vagus nerve stimulation (aVNS/taVNS), that relays the stimuli to the brainstem and higher brain regions via extensive projections to second and...


Peripheral effects of vagus nerve stimulation on anxiety and extinction of conditioned fear in rats. Citation: (Noble 2019)

Vagus nerve stimulation (VNS) has been shown to enhance extinction of conditioned fear in rats. Previous findings support this finding. It is hypothesized that this is the result of enhanced consolidation of extinction memories through the promotion of plasticity in related neural pathways. There are other explanations as well. The work supports rapidly expanding research into VNS, both invasive VNS and transcutaneous VNS (which is most often applied at the ear, e.g. transcutaneous auricular ...


How Does Eye Movement Desensitization and Reprocessing Therapy Work? A Systematic Review on Suggested Mechanisms of Action. Citation: (Landin-Romero 2018)

From eighty-seven studies three overarching models were identified as possible mechanism of action in EMDR: (i) psychological models (ii) psychophysiological models and (iii) neurobiological models. Read the full analyses and discussion in the paper presented on PubMed from Frontiers in Psychology. Reference: Landin-Romero R, Moreno-Alcazar A, Pagani M, Amann BL. How Does Eye Movement Desensitization and Reprocessing Therapy Work? A Systematic Review on Suggested Mechanisms of Action. Front P...


Auricular Chromotherapy in the Treatment of Psychologic Trauma, Phobias, and Panic Disorder. Citation: (Yoshizumi 2018)

The use of auricular methods for application in the field of psychology is supported by research such as the positive treatment results from auricular chromotherapy presented by Alexandre Massao Yoshizumi, MS, Daniel Guillermo Asis, MD, and Fabiola Andrade Luz, PhD. The auricular chromotherapy protocol, a technique developed by Dr. Asis and Dr. Federico Zarragoicoechea (with contributions from Jorge Boucinhas and Rafäel Nogier, MD), shows that simple auricular methods — methods that require l...


Neurophysiologic effects of transcutaneous auricular vagus nerve stimulation (taVNS) via electrical stimulation of the tragus: A concurrent taVNS/fMRI study and review. Citation: (Badran 2017)

Since prior studies of transcutaneous auricular vagus nerve stimulation (taVNS) with functional magnetic resonance imaging (fMRI) have had inconsistent findings (owing to variability in stimulation targets and parameters), the authors undertook to develop a transcutaneous auricular vagus nerve stimulation (taVNS)/functional magnetic resonance imaging (fMRI) system enabling the comparison of taVNS in relation to control stimulation through concurrent electrical stimulation and fMRI acquisit...


Non-invasive Vagal Nerve Stimulation Effects on Hyperarousal and Autonomic State in Patients with Posttraumatic Stress Disorder and History of Mild Traumatic Brain Injury: Preliminary Evidence. Citation: (Lamb 2017)

Posttraumatic stress disorder (PTSD) is a result of chronic stress that mobilizes  the autonomic nervous system, and may be reflected by chronic disinhibition of limbic structures. Mild traumatic brain injury commonly precedes PTSD in populations such as veterans, owing to the vulnerability of white matter in these networks. Such damage may affect response to treatment of PTSD. The authors evaluated transcutaneous vagal nerve stimulation (tVNS or taVNS), a non-invasive, low-risk neuro-auricul...


Novel Neuromodulation Techniques to Assess Interhemispheric Communication in Neural Injury and Neurodegenerative Diseases. Citation: (Shin, 2017)

Interhemispheric interaction has a major role in various neurobehavioral functions. Its disruption is a major contributor to the pathological changes in the setting of brain injury such as traumatic brain injury, peripheral nerve injury, and stroke, as well as neurodegenerative diseases. Shin and Pelled provide a review (yielding approximately 170 relevant articles) of noninvasive and state-of-the-art molecular based neuromodulation methods that focus on or have the potential to elucidate int...


The National Acupuncture Detoxification Association protocol, auricular acupuncture to support patients with substance abuse and behavioral health disorders: current perspectives. Citation: (Sturt 2016)

The National Acupuncture Detoxification Association (NADA) protocol, developed during an era of surging opiate use and addiction, is known as a cost-effective means to quickly reach and help treat populations that are often considered the most difficult to treat.  This 2016 review by Stuyt & Voyles is drawn from a range of small positive studies that offer testimony, “perhaps more appropriate to the reality of NADA practice today” of effectiveness for supportive intervention. NADA protoco...


NADA Protocol in Addictions. Citation: (Carter 2014)

The NADA protocol is a nonverbal, evidence-based best practice intervention with immediate calming effects on patients, regardless of the specific substance used, or whether a coexisting psychiatric disorder has been diagnosed. Initial participation with this 5-point protocol improves involvement in the treatment process.  Read more for context and continuing education options for nursing and mental health professionals   Citation: Carter K, Olshan-Perlmutter M. NADA Protocol: Integrative ...